Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Bill Murray
Frank Detorre
Molly Shannon
Mrs. Boyd
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Sherry Lynn
(voice)
Mickie McGowan
Additional Character Voice (voice)
Chris Elliott
Bob
Elena Franklin
Shane Detorre
Kid Rock
Kidney Rock
Uncle Kracker
Kidney Rock (voice)
Carlos Alazraqui
Additional Character Voices (voice)
Rodger Bumpass
Additional Character Voices (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Danny Mann
Additional Character Voices (voice)
Mickie McGowan
Additional Character Voices (voice)
Jonathan Adams
Additional Character Voices (voice)
Zak Penn
Producer
Marc Hyman
Screenplay
Peter Farrelly
Director
Stephen Schaffer
Editor
Bobby Farrelly
Director
Bradley Thomas
Producer
Mark Irwin
Director of Photography
Peter Farrelly
Producer
Lois Freeman-Fox
Editor
Randy Edelman
Original Music Composer
Sam Seig
Editor
Bobby Farrelly
Producer
Adam Beck
Animation
Paul Dutton
Animation
Jeannine Berger
Post Production Supervisor
Audrey Stedman
Layout
Karen Hamrock
Layout
Bob Camp
Storyboard
Eddie Rosas
Animation
Bill Perkins
Layout
Jennifer Yuan
Layout
Earl A. Hibbert
Visual Effects
Marc S. Fischer
Co-Producer
Arlan Jay Vetter
Art Direction
Hani D. El-Masri
Visual Development
Darek Gogol
Visual Development
Kevin Johnson
Visual Development
Leon Delaney
Stunt Coordinator
Steve Fonti
Storyboard
John Walker
Associate Producer
Chris Aguirre
Visual Development
Aaron Parry
Associate Producer
Jeff Etter
Visual Development
Ricardo F. Delgado
Visual Development
Katherine C. Concepcion
Art Department Manager
William 'Billy Jack' Jakielaszek
Special Effects Coordinator
John Bermudes
Special Effects
Carol Koch
Sculptor
Ruben Chavez
Visual Development
Daan Jippes
Storyboard
Mark Andrews
Storyboard
Barry Caldwell
Storyboard
John Harajovic
Special Effects
Craig R. Maras
Animation
Randy Sanchez
Animation
James P. Alles
Layout
John Williamson
Animation
Sam Chou
Animation
Joe Giampapa
Animation
Shane Prigmore
Animation
Fred Cline
Visual Development
Hal Olofsson
First Assistant Director
Joe Rossi
Makeup Department Head
Sydney J. Bartholomew Jr.
Production Design
Pamela Withers
Costume Design
Randy Thom
Sound Designer
Darlie Brewster
Supervising Animator
Rick Montgomery
Casting
Stephan Franck
Lead Animator
Ian Mah
Visual Effects Supervisor
Steven Burch
Special Effects Supervisor
Brenda McNally
Hair Department Head
Ken Ross
Music Supervisor
Scott Jacobson
Set Decoration
Dennis Edwards
Producer
Alan J. Hagge
Systems Administrators & Support
Louis Gonzales
Layout
Moroni Taylor
Storyboard Artist
Ricardo Curtis
Supervising Animator