Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Elena Franklin
Shane Detorre
Bill Murray
Frank Detorre
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Kid Rock
Kidney Rock (voice)
Molly Shannon
Mrs. Boyd
Chris Elliott
Bob
Jonathan Adams
Officer Tom (voice)
Carlos Alazraqui
Spanish Germ (voice)
Keith Anthony
Additional Character Voices (voice)
Eddie Barth
Conductor (voice)
Sally Brooks
Additional Character Voices (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Michael Carven
Additional Character Voices (voice)
Paul Christie
Dan Matter / Germ (voice)
Janis Dardaris
Additional Character Voices (voice)
Wendy Dillon
Additional Character Voices (voice)
Antonio Fargas
Chill the Flu Shot (voice)
Eddie Frierson
Frank Police Department Officer (voice)
Donald Fullilove
Doughnut (voice)
Jackie Gonneau
Additional Character Voices (voice)
Shannon Gregory
Additional Character Voices (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Rif Hutton
Charlie (voice)
Art Kimbro
Additional Character Voices (voice)
Joyce Kurtz
Additional Character Voices (voice)
Anne Lockhart
Female Red Blood Cell (voice)
Sherry Lynn
Trudy (voice)
Danny Mann
Musician Cell (voice)
Mickie McGowan
Brain Librarian (voice)
Kenny Olson
Kidney Rock Band (voice)
Jason Krause
Kidney Rock Band (voice)
Joe C.
Kidney Rock Band (voice)
Stefanie Eulinberg
Kidney Rock Band (voice)
Jimmie Bones
Kidney Rock Band (voice)
Uncle Kracker
Kidney Rock Band (voice)
Joel Silver
Police Chief (voice) (uncredited)
David Ossman
Scabies (voice) (uncredited)
John Melendez
Artie (voice)
Héctor Mercado
Additional Character Voices (voice)
Paul Pape
Male Red Blood Cell #2 (voice)
Marilyn Pasekoff
Additional Character Voices (voice)
Chris Phillips
Firefighter Doug (voice)
Lynne Redding
Additional Character Voices (voice)
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
Herschel Sparber
Bruiser (voice)
Doug Stone
Police Officer Jamie (voice)
Steve Susskind
Mob Boss Germ (voice)
Keri Tombazian
Additional Character Voices (voice)
Paul Tuerpe
Additional Character Voices (voice)
Robert Wisdom
Big Germ (voice)
Danny Murphy
Zookeeper Superintendent
Jack McCullough
Zookeeper
Will Dunn
Oyster Boy
Jackie Flynn
School Janitor
Kelsey Jordan
Bus Girl #1
Abe Farrelly
Bus Girl #2
Jesse Peter
Laughing Boy
John-Eliot Jordan
Pea Soup Manager
Nancy Byers
Pea Soup Supervisor
Kevin J. Flynn
Docky's Clamshack Waiter
Sean Gildea
Dreamy Photographer
Kathryn Frick
Nurse #1
Nikki Tyler-Flynn
Nurse #2
Elizabeth Jordan
Nurse #3
Zen Gesner
ER Doctor #1
Marc Hyman
ER Doctor #2
Zak Penn
ER Doctor #3
Diane Conrad
Zoo Visitor or Staff
Judith Conrad
Zoo Visitor or Staff
Thomas Jordan
The Zoo Visitor or Staff
Sydney J. Bartholomew Jr.
Zoo Visitor or Staff
Erica Johnson
Zoo Visitor or Staff
Bo Cleary
Pea Soup Staff
Bruce McIntyre
Pea Soup Staff
Colleen O'Donnell
Docky's Clamshack
Docky
The Bikini Gang
Joe Murphy
The Bikini Gang
Brian Mone
Police Officer
Sean Fitzgerald
Police Officer
Grace Costa
ER Nurse
Emily O’Donnell
School Girl
Bobby Farrelly
Director
Bobby Farrelly
Producer
Peter Farrelly
Producer
Zak Penn
Producer
Bradley Thomas
Producer
Randy Edelman
Original Music Composer
Mark Irwin
Director of Photography
Lois Freeman-Fox
Editor
Stephen Schaffer
Editor
Sam Seig
Editor
Peter Farrelly
Director
Adam Beck
Animation
Paul Dutton
Animation
Jeannine Berger
Post Production Supervisor
Audrey Stedman
Layout
Karen Hamrock
Layout
Bob Camp
Storyboard
Eddie Rosas
Animation
Bill Perkins
Layout
Jennifer Yuan
Layout
Earl A. Hibbert
Visual Effects
Marc S. Fischer
Co-Producer
Aaron Parry
Associate Producer
John Walker
Associate Producer
Arlan Jay Vetter
Art Direction
Chris Aguirre
Visual Development
Barry Caldwell
Storyboard
Ruben Chavez
Visual Development
Katherine C. Concepcion
Art Department Manager
Ricardo F. Delgado
Visual Development
Hani D. El-Masri
Visual Development
Jeff Etter
Visual Development
Steve Fonti
Storyboard
Darek Gogol
Visual Development
Daan Jippes
Storyboard
Kevin Johnson
Visual Development
Leon Delaney
Stunt Coordinator
John Bermudes
Special Effects
John Harajovic
Special Effects
William 'Billy Jack' Jakielaszek
Special Effects Coordinator
Carol Koch
Sculptor
Craig R. Maras
Animation
Randy Sanchez
Animation
James P. Alles
Layout
John Williamson
Animation
Joe Giampapa
Animation
Sam Chou
Animation
Shane Prigmore
Animation
Fred Cline
Visual Development
Stephan Franck
Lead Animator
Ian Mah
Visual Effects Supervisor
Darlie Brewster
Supervising Animator
Rick Montgomery
Casting
Steven Burch
Special Effects Supervisor
Sydney J. Bartholomew Jr.
Production Design
Scott Jacobson
Set Decoration
Pamela Withers
Costume Design
Brenda McNally
Hair Department Head
Joe Rossi
Makeup Department Head
Hal Olofsson
First Assistant Director
Ken Ross
Music Supervisor
Randy Thom
Sound Designer
Dennis Edwards
Producer
Alan J. Hagge
Systems Administrators & Support
Louis Gonzales
Layout
Ricardo Curtis
Supervising Animator
Dean Wellins
Supervising Animator
Marc Hyman
Writer
Steve Pilcher
Production Design
Michel Gagné
Visual Effects Designer
Piet Kroon
Animation Director
Tom Sito
Animation Director
Richard Bazley
Supervising Animator
Tony Fucile
Supervising Animator
Wendy Perdue
Supervising Animator
Mark Kausler
Storyboard
Duncan Marjoribanks
Lead Animator
Lennie K. Graves
Lead Animator
Mike Nguyen
Lead Animator
Fergal Reilly
Storyboard
Jeff Siergey
Storyboard
Hank Mayo
Storyboard
Moroni Taylor
Storyboard
Stephan Franck
Storyboard
Wilbert Plijnaar
Storyboard
Peter Sohn
Animation
T.J. House
Animation
Mark Kausler
Animation
Barry O'Donoghue
Animation
Craig Valde
Animation
Mark Andrews
Head of Story
Jae H. Kim
Animation
Gabe Hordos
Animation
Troy Quane
Animation
Daniel Lafrance
Animation
Richard Baneham
Animation
Frank Molieri
Animation
Mike Chavez
Animation
Jim Van der Keyl
Animation
Ruth Daly
Animation
Melina Sydney Padua
Animation
Michael Venturini
Animation
Ralph Fernan
Animation
Chris Waugh
Animation
Andrew L. Schmidt
Animation
David A. Zaboski
Animation
Holger Leihe
Animation
Line Korsgaard Andersen
Animation
Morgan Ginsberg
Animation
Keith Nicholson
Animation
Steve Baker
Animation
Daryl Graham
Animation
Dennis Pena
Animation
Shannon Penner
Animation
Trevor Deane-Freeman
Animation
Satjit Matharu
Animation
Tony Tupilano
Animation
Kevin Micallef
Animation