Gary Cooper
Henry Louis 'Lou' Gehrig
Teresa Wright
Eleanor Twitchell
Babe Ruth
Babe Ruth
Walter Brennan
Sam Blake
Dan Duryea
Hank Hanneman
Elsa Janssen
Christina 'Mom' Gehrig
Ludwig Stössel
Henry 'Pop' Gehrig
Virginia Gilmore
Myra Tinsley
Bill Dickey
Bill Dickey
Ernie Adams
Miller Huggins
Pierre Watkin
Mr. Twitchell
Harry Harvey
Joe McCarthy
Bob Meusel
Robert W. Meusel (as Robert W. Meusel)
Mark Koenig
Mark Koenig
Bill Stern
Bill Stern
Addison Richards
Coach
Hardie Albright
Van Tuyl
Edward Fielding
Clinic Doctor
George Lessey
Mayor of New Rochelle
Edgar Barrier
Hospital Doctor
Douglas Croft
Lou Gehrig as a Boy
Gene Collins
Billy (Age 8)
David Holt
Billy (Age 17)
Veloz
Specialty Dancer (as Veloz and Yolanda)
Yolanda
Specialty Dancer (as Veloz and Yolanda)
Ed Agresti
Barber (uncredited)
Ernie Alexander
Bellhop with Flowers (uncredited)
Hooper Atchley
Lathered Man in Barber Shop (uncredited)
Edwin August
Restaurant Patron (uncredited)
Bettye Avery
Nightclub Singer (uncredited)
Becky Bohanon
Little Girl (uncredited)
Lynton Brent
Photographer in Hospital (uncredited)
Roy Brent
Yankee Ballplayer (uncredited)
Betty Brewer
Little Girl (uncredited)
Don Brodie
Girl Show Barker (uncredited)
Charles Cane
Plumber (uncredited)
Jack Carr
Plumber (uncredited)
Burr Caruth
Village Storekeeper (uncredited)
Eddy Chandler
Motorcycle Cop #2 (uncredited)
Lane Chandler
Mark - Player in Locker Room (uncredited)
Bill Chaney
Newsboy (uncredited)
Jack Chapin
Photographer (uncredited)
Janet Chapman
Tessie (uncredited)
Spencer Charters
Mr. Larsen (uncredited)
Porter Chase
Weight Guesser (uncredited)
Dane Clark
Fraternity Boy (uncredited)
Heinie Conklin
Wallpaper Hanger (uncredited)
Hal Cooke
Man in Cab (uncredited)
Clancy Cooper
Motorcycle Cop #1 (uncredited)
John Daheim
Reporter in Hospital (uncredited)
Eva Dennison
Mrs. Worthington (uncredited)
Lester Dorr
Disappointed Fan #1 (uncredited)
Peter Du Rey
Photographer in Hospital (uncredited)
Lorna Dunn
Clinic Nurse (uncredited)
Jim Farley
Spectator (uncredited)
Frank Faylen
Yankee Third Base Coach (uncredited)
Walter Fenner
Dentist (uncredited)
Pat Flaherty
Yankee Ballplayer (uncredited)
Rosina Galli
Mrs. Fabrini (uncredited)
Vaughan Glaser
Doctor in Gehrig Home (uncredited)
Mary Gordon
Maid (uncredited)
Herschel Graham
Spectator (uncredited)
George Guhl
Second Paper Hanger (uncredited)
Eddie Hall
Reporter in Hospital Room (uncredited)
Harry Hayden
Department Store Manager (uncredited)
Vinton Hayworth
Fraternity Boy (uncredited)
Oscar 'Dutch' Hendrian
Furniture Mover (uncredited)
John Hiestand
Announcer (uncredited)
Earle Hodgins
Bottle Game Operator (uncredited)
Fay Holderness
Spectator (uncredited)
John Ince
Man in Box Seat (uncredited)
Mitchell Ingraham
Barber (uncredited)
Charles Irwin
Carnival Batting Game Operator (uncredited)
Jack Irwin
Photographer in Hospital (uncredited)
Sheldon Jett
Sportsman at Ballgame (uncredited)
Payne B. Johnson
Boy in Ball Park (uncredited)
John Kellogg
Fraternity Boy (uncredited)
Colin Kenny
Yankee Player on Train (uncredited)
Donald Kerr
Photographer (uncredited)
Richard Kipling
Broker (uncredited)
Pat Lane
Wheel of Chance Barker (uncredited)
Larry Lawson
Barker (uncredited)
Rex Lease
Spectator (uncredited)
Theodore Lorch
Neighbor Leaning Through Window (uncredited)
Frank Lyman
Fraternity Boy (uncredited)
Wilbur Mack
Man Outside Yankee Stadium (uncredited)
Dave Manley
Mayor Fiorello LaGuardia (uncredited)
Maurice Marks
Player (uncredited)
Francisco Marán
Rathskeller Headwaiter (uncredited)
John C. McCallum
Minor Role (uncredited)
Ralph McCullough
Reporter in Hospital (uncredited)
George McDonald
Wally Pipp (uncredited)
Matt McHugh
Strength Machine Operator (uncredited)
James McNamara
Rathskeller Manager (uncredited)
Wilmuth Merkyl
Spectator (uncredited)
Howard M. Mitchell
Sportsman at Ballgame (uncredited)
Irving Mitchell
Headwaiter (uncredited)
Pat Moriarity
Policeman in 1915 (uncredited)
Tom Neal
Fraternity Boy (uncredited)
Ray Noble
Orchestra Leader (uncredited)
Patsy O'Byrne
Scrubwoman (uncredited)
George Offerman, Jr.
Freshman (uncredited)
John B. Old
Reporter (uncredited)
Garry Owen
Scorecard Vendor (uncredited)
Sarah Padden
Mrs. Roberts (uncredited)
Emory Parnell
Chicago Policeman O'Doul (uncredited)
Edward Peil Sr.
Policeman (uncredited)
Tom Quinn
Reporter in Hospital (uncredited)
Cyril Ring
Photographer (uncredited)
Henry Roquemore
Disappointed Fan #2 (uncredited)
Art Rowlands
Telephone Man (uncredited)
William Roy
Joe Fabrini (uncredited)
Rip Russell
Laddie (uncredited)
Francis Sayles
Cab Driver (uncredited)
Anita Sharp-Bolster
Sasha's Mother (uncredited)
C. Montague Shaw
Mr. Worthington (uncredited)
Jack Shea
Hammond (uncredited)
John Sheehan
First Paper Hanger (uncredited)
Jack Stewart
Ed Barrow (uncredited)
Brick Sullivan
Policeman (uncredited)
Ben Taggart
Conductor (uncredited)
Walter Tetley
Cake Delivery Boy (uncredited)
Jimmy Valentine
Sasha - Boy Playing Baseball (uncredited)
Gohr Van Vleck
Furniture Mover (uncredited)
Dorothy Vaughan
Eleanor's Landlady (uncredited)
Dorothy Vernon
Family Friend (uncredited)
Malcolm Waite
Big Strength Machine Contestant (uncredited)
James Westerfield
Spectator (uncredited)
Guy Wilkerson
Sportsman at Ballgame (uncredited)
Max Willenz
Mr. Colletti (uncredited)
Buddy Williams
Bootblack (uncredited)
Charles Williams
Little Strength Machine Contestant (uncredited)
Robert Winkler
Murphy (uncredited)
Allen Wood
Freshman (uncredited)
Mike Donovan
Dick Gordon
Radio Listener (uncredited)
Charles Flynn
Fraternity Boy (uncredited)
Jack Gardner
Anthony Walters
Merril (uncredited)
Samuel Goldwyn
Producer
Sam Wood
Director
Leigh Harline
Original Music Composer
Daniel Mandell
Editor
Rudolph Maté
Director of Photography
Fletcher Henderson
Music Arranger
Norbert A. Myles
Makeup Artist
Irving Berlin
Songs
John Daheim
Stunts
Paul Gallico
Original Story
Howard Bristol
Set Decoration
John Sherwood
Assistant Director
Frank Maher
Sound Recordist
Perry Ferguson
Art Direction
William Cameron Menzies
Production Design
Herman J. Mankiewicz
Screenplay
René Hubert
Costume Design
Jo Swerling
Screenplay
Mel Berns
Makeup Artist
Albert Simpson
Matte Painter