01. End of the Line Part 1
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02. End of the Line Part 2
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03. Breathe Deeply...
The consequences of the train crash begin to hit home. Comfort struggles to come to terms with what has happened. And Jim warns Nikki not to get involved with Paul.
04. Perks of the Job
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05. Flash in the Pan
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06. Against Protocol
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07. Can't Let Go
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08. Truth or Dare
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09. In the Frame
Comfort is disgusted when female members of staff strike raunchy poses for a charity calendar, and Tally works out that Harry has been self-prescribing.
10. Black Dog Day
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11. Falling for a Friend
Harry's attempt to kiss Lara at the calendar launch backfires, Comfort is led astray by a friend out for a good time, and Roxy confesses to being a surrogate mother.
12. Second Best
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13. First Impressions
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14. Christmas Spirit
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15. Never Judge a Book
Jim whisks Nikki away for a cosy weekend at his remote country house, Bex drowns her sorrows in wine and cigarettes, and Charlie's son finally responds to treatment.
16. Eat, Drink and Be Merry
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17. I Got It Bad and That Ain't Good
I Got It Bad and That Ain't Good: Luke feels responsible for a man's death at an Army barracks, while the love triangle between Baz, Dan and Charlie reaches a dramatic climax.
18. Ahead of the Game
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19. Where There's Life...
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20. No Weddings and a Funeral
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21. Emotional Rescue: Part 1
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22. Emotional Rescue: Part 2
Lara dives underwater to save Simon, Fin sends Comfort home drunk and Jim struggles to keep order when the hospital is besieged by patients.
23. Passions and Convictions
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24. Fallen Hero
Valentine's Day proves traumatic for the staff at Holby A&E, as Nikki tries to decide what to do about her pregnancy, and Comfort and Fin struggle to handle their break-up.
25. Taking Care
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26. What Parents Do
The attraction between Simon and Lara proves too strong to resist, Roxy tries to stop Nikki going ahead with the termination and Comfort misses her counselling session.
27. Love and Loathing
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28. Finding Faith
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29. Parenthood
Roxy goes into premature labour, causing Nikki to put her grievances aside to help deliver the baby in the back of her car.
30. Another Perfect Day
Roxy gives her baby away, but the new parents are far from happy with the bundle of joy. Comfort prepares for her last day, and Tally manipulates her father.
31. I Love You, I Hate You
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32. Forget Me Not
Tally hits rock bottom after Harry suspends her and Simon tells her she was his biggest mistake, while Roxy faces heartbreak when the surrogate parents want the baby.
33. Lock Down
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34. Much Wants More
Abs is attacked by a man who blames him for the death of his child, while Harry realises he has been neglecting Tally and suggests they take a holiday together.
35. Breaking Point
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36. Don't Go There
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37. World Gone Wrong: Part 1
Harry's return to work prompts Charlie to draft his resignation letter, Fin and Comfort enjoy a romantic picnic, while Nikki and Lara are taken hostage.
38. World Gone Wrong: Part 2
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39. The Good Father
Nikki's slow recovery from the fall is set back by devastating news, Luke reluctantly attends the inquest, and Kate insists Greg's death was his fault.
40. Dreams and Disappointments
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41. And the Bride Wore Red
New paramedic Nina makes a bad impression, Josh's date with Caroline turns out to be an unmitigated disaster, and Lara is forced to take desperate measures.
42. A Dangerous Initiative
Nina annoys the rest of her team by playing the heroine. Simon is summoned to see Harry, Caroline pulls away from Josh, and Bex is on cloud nine.
43. Inside Out
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44. Who Cares
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45. Love, Honour and Betray
Tess treats a woman who has been severely beaten, and attempts to find out how she came by her injuries, while Simon and Lara celebrate their stag and hen nights.
46. Ring of Truth
Lara's big day is put in jeopardy when Abs makes a shocking discovery and the plane taking Simon to the wedding crashes and explodes.