

After her grandson's death, an old woman consults Holmes, after refusing a strange offer to buy her house including all its contents.

When Victor Savage begins using opium and behaving strangely, his wife consults Holmes. Victor dies, and Holmes suspects his cousin, knowledgeable in rare diseases.

Holmes and Mycroft investigate the murder of a professor's assistant who died clutching a woman's pince-nez.

Mrs. Hudson asks Holmes to help her friend with a lodger who insists on nobody entering his room, and his secret past is uncovered.